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Chemical Probes
JQ1
Bromodomain inhibitor.
Related literature:
Selective inhibition of BET bromodomains.
Filippakopoulos P et al. Nature 2010 4681067-73. PMID:20871596 Free PMC ArticleSimilar articles
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Delmore JE et al. Cell 2011 146(6):904-17. PMID: 21889194 Free PMC Article
Bromodomain inhibitor.
Related literature:
Selective inhibition of BET bromodomains.
Filippakopoulos P et al. Nature 2010 4681067-73. PMID:20871596 Free PMC ArticleSimilar articles
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Delmore JE et al. Cell 2011 146(6):904-17. PMID: 21889194 Free PMC Article
JQEZ5
EZH2 inhibitor.
Related literature:
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Zhang H et al. Cancer Discovery 2016 6(9)1006-21 PMID: 27312177 Free PMC Article
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.
Souroullas GP et al. Nature Medicine 2016 22(6) 632-40. PMID: 27135738 Free PMC Article
Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.
Xie H et al. Cancer Discovery 2016 6(11):1237-1247. PMID:27630126 Free PMC Article
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
Chen L et al. Journal of Clinic Investigation 2017 PMID: 29202477 Free Article
EZH2 inhibitor.
Related literature:
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Zhang H et al. Cancer Discovery 2016 6(9)1006-21 PMID: 27312177 Free PMC Article
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.
Souroullas GP et al. Nature Medicine 2016 22(6) 632-40. PMID: 27135738 Free PMC Article
Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.
Xie H et al. Cancer Discovery 2016 6(11):1237-1247. PMID:27630126 Free PMC Article
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
Chen L et al. Journal of Clinic Investigation 2017 PMID: 29202477 Free Article